中国药业Issue(17)：93-94,95,3.
匹维溴胺联用度洛西汀治疗肠易激综合征69例
Effect Observation of Pinaverium Bromide Combined with Low-Dose Dutoxetine in Treating Irritable Bowel Syndrome in 69 Cases
张存良 1姚路静 1昝松波1
作者信息
- 1. 河南省洛阳市第三人民医院消化内科，河南 洛阳 471002
- 折叠
摘要
Abstract
Objective To investigate the clinical effects of pinaverium bromide combined with low-dose dutoxetine in treating irritable bowel syndrome ( IBS ) in order to provide the important reference for clinic. Methods 138 patients with IBS were randomly divided into 2 groups. The experimental group was treated with pinaverium bromide combined with dutoxetine, while the control group was treated with simple pinaverium bromide for consecutive 8 weeks. The clinical efficacy was evaluated at the ends of 1, 2, 4, 8 weeks of treatment respectively. The symptoms improvement situation and the occurrence of adverse reactions were recorded. Resuts The clinical efficacy after 1-week treatment had no statistical difference between the two groups ( P>0. 05 ) , while which at the ends of 2, 4, 8 weeks the difference between the two groups ( P<0. 05 );especially the difference at the end of 8 weeks was more significant. The clinical total ef-fective rate was 91. 3% in the experimental group and 73. 9% in the control group. The depression symptom after treatment in the two groups were improved to some extent, but the improvement in the experimental group was more significant, the difference had statistical significance ( P<0. 05 ) . The adverse reactions occurred in the two groups without statistical difference ( P>0. 05 ) . Conclusion Pinaveri-um bromide combined with low-dose dutoxetine in treating IBS can effectively relieve the gastrointestinal symptoms, has rapid effect onset, lasting effect and better therapeutic effect than simple pinaverium bromide, which is worthy of being promoted and applied in clinic.关键词
肠易激综合征/匹维溴胺/度洛西汀/疗效Key words
irritable bowel syndrome/pinaverium bromide/dutoxetine/effect comparative research分类
医药卫生引用本文复制引用
张存良,姚路静,昝松波..匹维溴胺联用度洛西汀治疗肠易激综合征69例[J].中国药业,2014,(17):93-94,95,3.
