中国药业Issue(17)：96-97,98,3.
小剂量沙利度胺联合泼尼松治疗原发性骨髓纤维化14例
Observation on Effect and Adverse Reactions of Low-Dose Thalidomide Combined with Prednisone in Treating Primary Myelofibrosis in 14 Cases
摘要
Abstract
Objective To explore the efficacy and safety of low-dose thalidomide combined with prednisone in the treatment of primary myelofibrosis. Methods 14 cases of primary myelofibrosis were treated with thalidomide combined with prednisone. The changes of blood routine and spleen size were observed. The curative effect was evaluated. At the same time the adverse reactions were closely ob-served. Resuts Of 14 cases of primary myelofibrosis, 10 cases obtained the clinical progress, among them, hemoglobin was increased in 7 cases ( 50. 00%) , platelet was increased in 3 cases ( 21. 43%) , spleen was diminished in 7 cases ( 50. 00%);3 cases were stable;1 case died of heart failure in 1 month after medication. 14 cases were tolerable to low-dose thalidomide and prednisone. The adverse reac-tions mainly were deadlimb, drowsiness, constipation, edema and fatigue, which were mild. Conclusion Thalidomide combined with pred-nisone has significant effect for treating primary myelofibrosis and the adverse reactions are tolerable.关键词
沙利度胺/骨髓纤维化/泼尼松Key words
thalidomide/myelofibrosis/prednisone分类
医药卫生引用本文复制引用
高辉,王建荣,胡凤霞,徐泽峰..小剂量沙利度胺联合泼尼松治疗原发性骨髓纤维化14例[J].中国药业,2014,(17):96-97,98,3.基金项目
山东省东营市科技计划专项基金项目，项目编号20121212。 （）
