摘要
Abstract
Objective To research the clinical effect of nicardipine combined with verapamil for inhibiting scar tissue. Methods 120 cases of scar tissue were randomly divided into the group A and B, 60 cases in each group;the group A was treated by nicardipine combined with verapamil; the group B was treated by nicardipine alone. The therapeutic effects after 2-year treatment were compared between the two groups. Results The area and thickness of scar tissue after 2-year treatment in the two groups were decreased;the scar proliferation index was declined. The improvement degree in the group A was better than that in the group B with statistical dif-ference ( t=5. 703 1, 14. 346 3, 5. 703 1; P=0. 000 0 );CD34 and the positive expression rate of proliferating cell nuclear antigen inside the scar tissue after treatment in the two groups were significantly decreased;the decrease degree in the group A was significantly su-perior to the group B ( t=23. 014 2, 16. 504 8; P=0. 000 0 );the contents of fibroblasts endothelin-1, hydroxyproline and proliferating cell nuclear antigen of the scar tissue after treatment in the two groups were reduced, but the improvement degree in the group A was superior to the group B ( t=6. 928 2, 26. 492 6, 6. 928 2; P=0. 000 0 ) . Conclusion Adopting nicardipine combined with verapamil can effectively inhibit the hyperplasia of scar tissue, reduces the size and thickness of scar tissue and has a certain clinical significance.关键词
瘢痕组织/尼卡地平/维拉帕米Key words
scar tissue/nicardipine/verapamil分类
医药卫生
