中国药业Issue(19)：24-25,26,3.
注射用硝普钠与葡萄糖注射液配伍稳定性研究
Study of Compatible Stability of Nitroprusside Sodium for Injection with Glucose Injection
摘要
Abstract
Objective To investigate the compatible stability of Nitroprusside Sodium for Injection ( SNP ) and 5% Glucose Injection ( 5%GS ) . Methods SNP and 5%GS were prepared into the compatible solution according to clinical demand. The stability of SNP compati-ble solution was investigated in different environments and different storage time, including the solution character, appearance, pH value, insoluble particle, ultraviolet-visible absorption and SNP content. Results The compatible solution of SNP mixed with 5% GS was sta-ble within 26 h keeping in dark place by lucifugal cover at 20℃ or 35℃. Under the any condition without keeping in dark place, the solution was unstable. The solution stability had no relation with the concentration and was closely correlated with the illumination in-tensity and time. Conclusion In the dark condition, the compatible solution of SNP and 5% GS is stable within 26 h.关键词
硝普钠/高效液相色谱法/配伍/稳定性Key words
sodium nitroprusside/HPLC/combination/stability分类
医药卫生引用本文复制引用
林小明,韦宝含,曾毅,韦平原,梁汉钦,谢伟乾,陈明忠..注射用硝普钠与葡萄糖注射液配伍稳定性研究[J].中国药业,2014,(19):24-25,26,3.基金项目
广西贵港市科技攻关项目，项目编号201305。 （）
