中国药业Issue(19)：85-86,87,3.
甲氨蝶呤不同给药途径对子宫切口妊娠的临床和超声学疗效比较
Comparison of Clinical Effects and Ultrasonic Changes of Different Administration Routes of Methotrexate for Treating Cesarean Scar Pregnancy
林洁 1郭道宁1
作者信息
- 1. 四川省绵阳市中心医院，四川 绵阳 621000
- 折叠
摘要
Abstract
Objective To observe the clinical effect of different administration routes of methotrexate for treating cesarean scar pregnan-cy. Methods 60 cases of cesarean scar pregnancy in our hospital from February 2010 to February 2013 were selected and randomly divided into the group A and B. Methotrexate was given by intramuscular injection in the group A and the group B by uterine arterial topical administration in the group B, respectively. The changes of ultrasonic acoustic images before and after treatment were observed in the two groups. The clinical effects after treatment were compared between the two groups. The adverse reactions were recorded. Results The ultrasonic results showed that the pregnancy tissue after treatment was shrunk compared with before treatment ( P<0. 05 ) , while the muscular thickness in the inferior segment of anterior wall and RI were significantly increased ( P<0. 05 ) , moreover which in the group B was more significant ( P<0. 05 );the rate of conversion to hysterectomy, treatment time before complete curettage of uterine cavity, in-traoperative blood loss, postoperative hospital stay, time of β-HCG dropping to normal level in the group B were lower or shorter than those in the group A ( P<0. 05 );the occurrence rate of adverse reactions in the group B was significantly lower than that in the group A. Conclusion Methotrexate has obvious clinical effect in treating cesarean scar pregnancy. The curative effect of uterine artery topical administration is better than that by the intramuscular injection. Compared with the systemic administration, the topical administration has the advantages of the short conservative treatment time, low rate of conversion to hysterectomy compare with the intramuscular injection treatment of short time, low transfer rate of hysterectomy, shorter postoperative hospitalization time and little adverse reactions and de-serves to be clinically promoted.关键词
甲氨蝶呤/切口妊娠/超声学/子宫动脉局部给药Key words
methotrexate/cesarean scar pregnancy/ultrasonics/uterine arterial topical administration分类
医药卫生引用本文复制引用
林洁,郭道宁..甲氨蝶呤不同给药途径对子宫切口妊娠的临床和超声学疗效比较[J].中国药业,2014,(19):85-86,87,3.
