摘要
Abstract
Objective To investigate the clinical efficacy and safety of Hydrotalcite Tablet combined with esomeprazole and mosapride in the treatment of gastroesophageal reflux disease. Methods 125 patients with gastroesophageal reflux disease were randomly divided into the observation group and the control group. 63 cases in the observation group were given the therapy of Hydrotalcite Tablets combined with esomeprazole and mosapride, while 62 cases in the control group were given the therapy of omeprazole combined with mosapridel. The clinical efficacy and safety were compared between the two groups. Results The symptom scores and the endoscopic examination scores after treatment in the two groups were significantly decreased, but the decrease in the observation group was more significant. From the aspect of the clinical curative effect, the total effective rate in the observation group was 96. 83%, which was high-er than 75. 81% in the control group, the difference between the two groups had statistical significance ( P<0. 05 ) . From the aspect of the endoscopic curative effect, the total effective rate in the observation group was 95. 24%, which was higher than 80. 64% in the control group, the difference between the two groups had statistical significance ( P<0. 05 ) . The occurrence rate of adverse reactions had no statistical difference between two groups ( 6. 34% vs. 6. 45%, P>0. 05 ) . Conclusion Hydrotalcite Tablet combined with esomeprazole and mosapride is significantly effective and safe in the treatment of gastroesophageal reflux disease and deserves to be promoted in clinic.关键词
铝碳酸镁片/埃索美拉唑/莫沙必利/胃食管反流病Key words
Hydrotalcite Tablet/esomeprazole/mosapride/gastroesophageal reflux disease分类
医药卫生
