摘要
Abstract
Objective To evaluate the in vivo pharmacokinetics of Valaciclovir Sustained Release Tablets in healthy volunteers. Methods The single oral dose of 300,600,900 mg of Valaciclovir Sustained Release Tablets was given to 8 healthy volunteers. The plasma concen-tration of acyclovir was determined by high performance liquid chromatography ( HPLC ) and the pharmacokinetic parameters were calcu-lated by the 3P97 software. Results After taking the single oral dose of 300,600,900 mg,AUC(0 -t) was (6. 90 ± 1. 20),(13. 34 ± 2. 34),(18. 53 ± 2. 45)μg · h/L,respectively;Cmax was (0. 49 ± 0. 12),(1. 03 ± 0. 22),(1. 34 ± 0. 21)μg/mL,respectively;t1 /2ke were (5. 23 ± 0. 67),(4. 15 ± 0. 44),(4. 37 ± 0. 34)h,respectively;tmax was (4. 84 ± 0. 66),(4. 23 ± 0. 62),(4. 63 ± 0. 52)h,respectively. Conclusion The researched and prepared Valaciclovir Sustained-Release Tablets meets the design requirements with significant sus-tained release effect.关键词
伐昔洛韦/阿昔洛韦/缓释/药代动力学/高效液相色谱法Key words
valaciclovir/acyclovir/sustained release/pharmacokinetics/high performance liquid chromatography(HPLC)分类
医药卫生
