中国药业Issue(21)：15-17,18,4.
美托洛尔对慢性心力衰竭患者Th17细胞功能的调节作用
Regulating Effect of Metoprolol on Th17 Cells in Patients with Chronic Heart Failure
张霞 1赵银萍 1唐其东 1吉家兴1
作者信息
- 1. 广东省第二人民医院药学部，广东 广州 510317
- 折叠
摘要
Abstract
Objective To investigate the regulating effect of metoprolol on peripheral blood Th17 cells in the patients with chronic heart failure ( CHF ) . Methods 80 patients with CHF were randomly divided into the conventional treatment group and the metoprolol group, 40 cases in each group. Other 40 individuals with healthy physical examination were selected as the control group. The two treatment groups were given angiotension converting enzyme inhibitor ( ACEI ) , diuretics and cardiac drugs. In addition the metoprolol group was added with metoprolol. The expression level of peripheral blood Th17 cells before treatment and at 6 months of treatment were detected by using the flow cytometry and the expression levels of serum IL-6, IL-17, IL-23 were detected by ELISA. Results The levels of serum IL-6, IL-17 and IL-23 levels before treatment in the CHF group were significantly higher than those in the healthy control group ( P<0. 05 ) , which after 3- month treatment in the metoprolol group and the conventional treatment group were significantly de-creased ( P<0. 01 ) , but the above indexes in the metoprolol group were significantly lower than the those in the conventional therapy group ( P<0. 05 ) . Conclusion The expression increase and hyperfunction of Thl7 cells exist in the patients with CHF, metoprolol may significantly down-regulate the expression frequency and function of Thl7 cells, which may be one of the metoprolol action mechanisms for improving the heart function from the immune aspect in the patients with CHF.关键词
β-受体阻滞剂/T辅助17型细胞/白细胞介素6/白细胞介素17/白细胞介素23/美托洛尔Key words
β-blockers/Th17/IL-6/IL-17/IL-23/metoprolol分类
医药卫生引用本文复制引用
张霞,赵银萍,唐其东,吉家兴..美托洛尔对慢性心力衰竭患者Th17细胞功能的调节作用[J].中国药业,2014,(21):15-17,18,4.
