中国药业Issue(23)：28-29,2.
神经节苷脂预防奥沙利铂致末梢神经毒性30例临床研究
Clinical Study on Gangliosides for Preventing Oxaliplatin Induced Peripheral Neurotoxicity in 30 Cases
王南瑶 1王琼 1费燕华 1袁明 1吴丹1
作者信息
- 1. 江苏省江阴市人民医院肿瘤科，江苏 无锡 214400
- 折叠
摘要
Abstract
Objective To observe the effects of gangliosides for preventing the oXaliplatin induced peripheral neurotoXicity. Methods 85 patients with colorectal cancer treated by oXaliplatin + fluorouracil + calcium folinate chemotherapeutical regimen(FOLFOX) were randomly divided into the three groups of gangliosides, calcium and magnesium(Ca / mg) miXture and simple chemotherapy. According to the spe-cific nerve toXicity grading standard of oXaliplatin, the neurotoXicity incidence and severity of all patients were observed. Results The neurotoXicity incidences of the gangliosides group, the Ca / mg miXture group and the simple chemotherapy group were 64. 28% , 66. 67%and 92. 59% respectively, the differences among them were statistically significant( P < 0. 05) . There were statistically significant differ-ences in chronic neurotoXicity after 4 and 8 cycles of chemotherapy among the three groups( P < 0. 05) . The grade I - Ⅲ neurotoXicity in the Ca / mg miXture group and the gangliosides group were lower than that in the simple chemotherapy group( P > 0. 05 ), but the dif-ference between the Ca / mg miXture group and the gangliosides group had no statistical significance. Conclusion Using gangliosides can prevent the neurotoXicity occurrence effectively, and can decrease the incidence and the lesion degree of oXaliplatin induced neurotoXicity.关键词
神经节苷脂/奥沙利铂/神经毒性Key words
gangliosides/oXaliplatin/neurotoXicity分类
医药卫生引用本文复制引用
王南瑶,王琼,费燕华,袁明,吴丹..神经节苷脂预防奥沙利铂致末梢神经毒性30例临床研究[J].中国药业,2014,(23):28-29,2.
