中国药业Issue(23)：37-38,39,3.
重组牛碱性成纤维细胞生长因子眼用凝胶和玻璃酸钠滴眼液治疗睑板腺异常相关干眼疗效比较
Comparative Study of Recombinant Bovine Basic Fibroblast Growth Factor Ophthalmic Gel and Sodium Hyaluronate Eye Drops for Treating Meibomian Gland Abnormality Related Dry Eye
摘要
Abstract
Objective To investigate the efficacy of Recombinant Bovine Basic Fibroblast growth Factor Ophthalmic gel and Sodium Hyaluronate Eye Drops for the treatment of meibomian gland abnormality related dry eye. Methods 73 patients (73 eyes) with meibo-mian gland abnormaly related dry eye in the department of ophthalmology of our hospital from march 2012 to march 2013 were ran-domly divided into the Recombinant Bovine Basic Fibroblast growth Factor Ophthalmic gel group (observation group) and Sodium Hyaluronate Eye Drops group( control group) . And the clinical symptom score, tear film breakup time ( BUT) , Schirmer test ( Schirmer Ia), corneal fluorescein staining score (FL) and meibomian gland score before treatment and on 15, 30 d after treatment were compared between the two groups. Results The clinical symptom scores, BUT and FL scores after 30 d treatment in the two groups were both better than those before treatment and after 15 d treatment (all P < 0. 05 ); the clinical symptom scores, BUT and FL scores after 30 d treatment in the observation group were better than those in the control group (all P < 0. 05); the Schirmer Ia and the meibomian gland score after treatment in the two groups had no improvement compared with before treatment(all P > 0. 05) . The effective rate of the observation group was higher than that of the control group and the total effect had statistically significant difference between the two groups( P < 0. 05) . Conclusion Recombinant Bovine Basic Fibroblast growth Factor Ophthalmic gel and Sodium Hyaluronate Eye Drops can both improve the clinical symptoms, prolong the tear film BUT and repair corneal damage for treating meibomian gland ab-normality related dry eye, but the former is more effective than the latter. The effects of both two methods for improving the meibomian gland dysfunction are poor, which needs to coordinated with other medication therapy.关键词
重组牛碱性成纤维细胞生长因子眼用凝胶/玻璃酸钠滴眼液/睑板腺异常/干眼/临床疗效Key words
recombinant bovine basic fibroblast growth factor ophthalmic gel/sodium hyaluronate eye drop/meibomian gland abnormality/dry eye/clinical efficacy分类
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王雪飞,覃冬菊,李明哲..重组牛碱性成纤维细胞生长因子眼用凝胶和玻璃酸钠滴眼液治疗睑板腺异常相关干眼疗效比较[J].中国药业,2014,(23):37-38,39,3.
