中国药业Issue(23)：61-62,2.
高效液相色谱法测定炎琥宁注射液中脱水穿心莲内酯琥珀酸半酯含量
HPLC Determination of Dehydroandrographolide Succinate Content in Potassium Sodium Dehydroandroandrographolide Succinate Injection
李卫红 1郭彩娥 2李晓燕 3赵靖 4贺华英1
作者信息
- 1. 河北省邯郸县医院，河北 邯郸 056000
- 2. 河北省邯郸市第一医院，河北 邯郸 056002
- 3. 河北省邯郸市中心医院，河北 邯郸 056001
- 4. 河北省邯郸市妇幼保健院，河北 邯郸 056001
- 折叠
摘要
Abstract
Objective To determine the content of dehydroandrographolide succinate in Potassium Sodium Dehydroandroandrographolide Succinate Injection by HPLC. Methods The determination was performed on the Agilent C18 column with acetonitrile - 0. 05 mol / mL potassium dihydrogen phosphate(35 : 65 ) as the mobile phase at a flow rate of 1. 0 mL / min and the detection wavelength of 251 nm. Results Dehydroandrographolide succinate in the range of 40 - 400 μg / mL showed the good linear relation with the peak area, the av-erage recovery rate was 98. 39% , RSD = 0. 7% ( r = 0. 999 9,n = 9) . Conclusion This quality control method can effectively control the quality of dehydroandrographolide succinate in Potassium Sodium Dehydroandroandrographolide Succinate Injection, which is simple with accurate results and high sensitivity.关键词
脱水穿心莲内酯琥珀酸半酯/炎琥宁注射液/高效液相色谱法Key words
dehydroandrographolide succinate/potassium sodium dehydroandroandrographolide succinate injection/HPLC分类
医药卫生引用本文复制引用
李卫红,郭彩娥,李晓燕,赵靖,贺华英..高效液相色谱法测定炎琥宁注射液中脱水穿心莲内酯琥珀酸半酯含量[J].中国药业,2014,(23):61-62,2.
