中国药业Issue(24)：29-30,2.
风湿骨痹口服液急性毒性研究
Acute Toxicity of Fengshigubi Oral Liquid
摘要
Abstract
Objective To observe the acute toxicity reaction of Fengshigubi Oral Liquid by gastric gavage in mice,and to determine LD50 and the maximum dosage to provide the basis for clinical safe medication. Methods The mice were given Fengshigubi Oral Liq-uid by gastric gavage. The median lethal dose( LD50) and the maximum dose were determined by the pre-experiment. Results LD50 was not detected out and the maximum dose in mice was 1 236 g crude drug/kg,which was equivalent to 1 799 times of human dosage in clinic,the gastric gavage of this dose had no acute toxicity in mice. Conclusion Fengshigubi Oral Liquid has low toxicity and it is safe under the clinical provision of usage and dosage.关键词
风湿骨痹口服液/急性毒性试验/半数致死量/最大给药量Key words
Fengshigubi Oral Liquid/acute toxicity tests/median lethal dose/maximum dose分类
医药卫生引用本文复制引用
辛玲歌..风湿骨痹口服液急性毒性研究[J].中国药业,2014,(24):29-30,2.基金项目
陕西省咸阳市2012科技计划项目，项目编号2012k16－04。 （）
