中国药业Issue(24)：35-37,3.
壮尔颗粒对小鼠T淋巴细胞亚群的影响
Influence of Zhuang'er Granules on T-lymphocytes Subsets in Mouse
摘要
Abstract
Objective To observe the effect of Zhuang'er Granules on the immune organ index and T-lymphocytes subsets in the cellu-lar immunosupressed mice. Methods The mouse model was established by cyclosporin A(CsA) and given Streptococcus pneumoniae (SP) by nasal drops on 7 d before detection. The mouse immune organ index was determined after 17 d intragastric gavage and the changes of T-lymphocyte subsets were detected by the flow cytometry(FACS). Results Compared with the blank control group,the thymus index and spleen index in the model group were obviously decreased( P ﹤ 0. 05);compared with the model group,which in each dose group were obviously increased( P ﹤ 0. 05),and obviously increased with dose increase( P ﹤ 0. 05);compared with the blank control group,for CD3 +,CD4 +,CD8+ in the spleen,CD3 + in the model group was declined obviously( P ﹤ 0. 05),CD4 + showed the de-cline trend and CD8 + model group had the rising trend;the percentage of CD3 +,CD4 + in each dose group was increased with dose in-crease,while the percentage of CD8+ was declined with dose increase;compared with the blank control group,for blood CD3 +,CD4 +, CD8 +,CD3+ in the model group showed the decline trend,CD4+ was obviously decreased( P ﹤ 0. 05)and CD8 + was obviously increased ( P ﹤ 0. 05),the percentage of CD3 +,CD4 + in each medication group was increased with dose increase( P ﹤ 0. 05),while the percent-age of CD8 + in each medication group was decreased with dose increase. Conclusion Zhuang'er Granules has the effect for improving the mice immune function,increases CD3 + and CD4+,simultaneously decreases CD8+,which could regulate the mice immune function via T-lymphocytes balance.关键词
壮尔颗粒/流式细胞术/免疫器官指数/T淋巴细胞亚群Key words
Zhuang'er Granules/flow cytometry/immune organ index/T-lymphocyte subsets分类
医药卫生引用本文复制引用
兰玉冰,张旭,程嘉艺..壮尔颗粒对小鼠T淋巴细胞亚群的影响[J].中国药业,2014,(24):35-37,3.基金项目
辽宁省沈阳市科技局重点项目，项目编号F11－264－1－73。 （）
