摘要
Abstract
Objective To investigate the clinical efficacy of oseltamivir in treating children influenza and its influence on serum cy-tokines. Methods 150 children patients with influenza admitted to our hospital from July 2012 to May 2013 were selected and ran-domly divided into the treatment group( n=75)and the control group( n=75). The control group was given oral Ribavirin Tablets,while the treatment group was given oral Oseltamivir Tablets. The course of treatment was 3 weeks. The clinical efficacies were compared be-tween the two groups. The improvement of symptoms and signs was observed. Serum cytokins levels of CRP,interferon-γ(IFN-γ), etc. were detected before and after treatment. Results The total effective rate in the treatment group was 90. 67%,which was signifi-cantly higher than 80. 00% in the control group( P ﹤ 0. 05);the defervesce time,improvement time of symptoms and signs such as cough,nasal congestion and throat congestion,and average disease course in the treatment group were significantly shorter than those in the control group( P ﹤ 0. 05). Serum CRP and IFN-γ levels in the two groups were significantly decreased compared with those before treatment( P ﹤ 0. 05),in which the decrease of IFN-γ level in the observation group was more significant( P ﹤ 0. 05). The occurrence rate of adverse reactions during treatment had no statistical difference between the two groups( P ﹥ 0. 05). Conclusion Oseltamivir has definite effect in treating children,does not affect the host cells with less adverse reactions,which is worth of clinical promotion.关键词
奥司他韦/小儿/流行性感冒/疗效/血清学指标/细胞因子Key words
oseltamivir/children/influenza/curative efficacy/serological index/cytokines分类
医药卫生
