摘要
Abstract
Objective To observe the clinical curative effect of alprostadil combined with mecobalamin in the treatment of diabetic pe-ripheral neuropathy ( DPN ) . Methods 74 patients of DPN were randomly divided into two groups. The control group ( n=37 ) was added with mecobalamin on the basis of comprehensive treatment and the observation group ( n=37 ) was added with alprostadil combined with methylcobalamin on the basis of the comprehensive treatment. The course of treatment in the two groups was 2 weeks. The clinical effi-cacy, motor and sensory nerve conduction velocity and adverse reaction before and after treatment were compared between the two groups. Results The total effective rate of the observation group was 86. 49%, which was significantly higher than 67. 57% of the con-trol group ( P<0. 05 );there was no statistically significant difference in the motor and sensory nerve conduction velocity before treatment between the two groups ( P>0. 05 ) , the motor and sensory nerve conduction velocity after treatment was significantly faster than that of before treatment ( P<0. 05 ) , moreover the observation group was more obvious than that the control group ( P<0. 05 );no serious adverse reactions happened in the two groups during treatment. Conclusion Alprostadil combined with mecobalamin for treating DPN has a sig-nificant efficacy and can significantly improve the motor and sensory nerve conduction velocity;it is worthy of popularization and appli-cation.关键词
前列地尔/甲钴胺/糖尿病周围神经病变Key words
mecobalamin/alprostadil/diabetic peripheral neuropathy分类
医药卫生
