摘要
Abstract
Objective To understand the clinical characteristics of adverse drug reactions ( ADR ) to offer reference for clinical rational drug use in future. Methods The clinical data of 1260 inpatients in the internal medicine department of our hospital from March. 2012 to May. 2013 were collected, in which 726 cases aged more than 49 years were selected as the research subjects. The general informa-tion, disease course, length of hospital stay, liver or renal function, ADR history, clinical manifestations, etc. were statistically ana-lyzed. Results There were 138 cases of ADR with the ADR occurrence rate of 19. 01% and the case-times rate of 21. 90%; the mild and moderate ADR was predominant, which accounted for 80. 43%. ADR occurred in 10 categories of drugs, which were mainly antimicrobial agents, accounted for 30. 19%, followed by the circulatory system drugs, accounted for 19. 50%, digestive system drugs was the third, accounted for 11. 32% ; the intravenous drip or intravenous injection were the main administration mode causing ADR ( 69. 18% );skin, digestive and nervous systems were the main ADR involving parts;91. 30% of cases were cured after actively symp-tomatic treatment. The single factor chi-square analysis found that females, the patients aged over 60 years old, with abnormal liver or renal function, past history of ADR, and the diseases more than 3 kinds were more likely to happen ADR, there were statistically signif-icant differences ( P< 0. 05 or P< 0. 01 ) . Conclusion The middle aged and elderly people have the higher occurrence rate of ADR. Recognizing the patients with susceptibility to ADR on admission and by combining the clinical characteristics of ADR can increase the rate of rational drug use, thus reduce the occurrence rate of ADR.关键词
药品不良反应/合理用药/干预措施Key words
adverse drug reaction/rational drug use/intervention measure分类
医药卫生
