摘要
Abstract
Objective To investigate the effect of telmisartan combined with α-lipoic acid on the insulin resistance in type 2 diabetes mellitus ( T2DM ) complicating non-alcoholic fatty liver disease ( NAFLD ) . Methods 62 patients with T2DM complicating NAFLD were randomly divided into the control group and the observation group. The control group was treated by glyburide, while on this basis the observation group was added with the intervention of telmisartan combined with α-lipoic acid. The two groups were treated for 8 weeks. The basic indexes changes of fast blood glucose ( FBG ) , postprandial 2 h glucose ( 2h PG ) , glycated hemoglobin, blood pressure and blood lipids were detected. The insulin and the homeostasis model assessment of insulin resistance ( HOMA-IR ) were calculated in the two groups. Result s The levels of insulin, HOMA-IR, blood lipids, FBG, 2h PG and glycated hemoglobin after treatment in the two groups were significantly decreased compared with before treatment ( P﹤0. 05 ) , while which in the observation was more significant ( P ﹤ 0. 05 ) . The blood pressure showed the downward trend, while which in the observation was more significant, but without statistical difference ( P ﹥0. 05 ) . Conclusion The therapy of telmisartan combined with α-lipoic acid can more significantly improve the insulin resistant effect than single use of glyburide, moreover has little effect on the basic indexes of blood pressure, etc. and is safe and better tolerable.关键词
替米沙坦/α-硫辛酸/2型糖尿病/非酒精性脂肪肝/胰岛素抵抗Key words
telmisartan/α-lipoic acid/type 2 diabetes mellitus/non-alcoholic fatty liver disease/insulin resistance分类
医药卫生
