中国药业Issue(5)：10-11,12,3.
瑞芬太尼复合咪达唑仑用于原发性高血压乳腺肿物切除术40例临床研究
Study on Clinical Application of Remifentanil Combined with Midazolam in Primary Hypertension Patients undergoing Breast Tumor Resection on 40 Cases
摘要
Abstract
Objective To investigate the anesthesia effect and safety of remifentanil combined with midazolam in primary hypertension pa-tients undergoing breast tumor resection. Methods According to the random number table method, 80 cases of grade ASA Ⅰ-Ⅱbreast tumor resection in the hospital from May 2011 to December 2013 were divided into the experimental group and the control group with 40 cases each. The experimental group adopted the intravenous anesthesia of remifentanil and midazolam anesthesia, while the control group adopted ketamine combined with midazolam for conducting intravenous anesthesia. The differences in the mean arterial pressure ( MAP ) , systolic blood pressure ( SBP ) , diastolic blood pressure ( DBP ) , heart rate ( HR ) , oxygen saturation ( SpO2 ) , OAA/S sedation score and occurrence rate of adverse reactions at 3 min after entering the operation room ( T1 ) , operation beginning ( T2 ) , at 5 min after operation beginning ( T3 ) , 10 min after operation beginning ( T4 ) , before leaving the operation room ( T5 ) were compared between the two groups. Results SpO2 at each time point had no obvious change in inter-group and intra-group. SBP, DBP and HR at T2 in the experi-mental group were significantly decreased than those at T1 ( P ﹤ 0. 05 ) , which at T3, T4 and T5 had no significant differences compared with those at T1;SBP, DBP and HR at T2, T5 had no significant change compared with those at T1 ( P ﹥ 0. 05 ) , but which at T3, T4 were obviously increased compared with those at T1. SBP, DBP and HR at T2, T3, T4 in the control group were significantly higher than those in the experimental group ( P ﹤ 0. 05 ) . The occurrence rates of respiratory depression, postoperative pain, vomiting and nausea had no sig-nificant differences between the two groups ( P ﹥ 0. 05 ) . The occurrence rates of hypertension and postoperative agitation in the experimental group were 2. 50% and 2. 50% respectively, which were significantly lower than 15. 00% and 20. 00% in the control group. Conclusion Compared with traditional ketamine combined with midazolam, remifentanil combined with midazolam for the intraoperative anesthesia in primary hypertension patients undergoing breast tumor resection has better anesthesia effect, less intraoperative hypertension, rapid postoper-ative recovery and lower agitation occurrence rate.关键词
咪达唑仑/瑞芬太尼/氯胺酮/乳腺肿物切除术/原发性高血压Key words
midazolam/remifentanil/ketamine/breast tumor resection/primary hypertension分类
医药卫生引用本文复制引用
齐爱玲,李月鹏,孟凡浩,张永昌,刘洪涛,张玲玲,张敏..瑞芬太尼复合咪达唑仑用于原发性高血压乳腺肿物切除术40例临床研究[J].中国药业,2015,(5):10-11,12,3.基金项目
河北省廊坊市科学技术局科研项目，项目编号2011013019。 （）
