摘要
Abstract
Objective To explore the effect of tolvaptan on improving the symptoms in the patients with heart failure and its influence on the cardial and renal function. Methods 146 patients with chronic heart failure admitted our hospital in 2013 were selected and divided into the observation group and the control group according to the random number table method,53 cases in each group. Both the two groups were treated with the conventional therapy of carditonic,diuretic,correcting water and electrolyte disturbance,etc. The ob-servation group was added with tolvaptan 15 mg/d. The symptoms improvement situation such as dyspnea,pulmonary rales and lower extremity edema were observed in the two groups. The changes of the cardial and renal function indexes after treatment were compared between the two groups. Results Compared with the control group,the heart failure symptoms of dyspnea,pulmonary rales and lower ex-tremity edema after treatment in the observation group were significantly improved,24 h urine output was significantly increased and BNP was significantly dropped( P < 0. 05),the renal function had no obvious deterioration. Conclusion Tolvaptan conduces to improve the discomfort symptoms in the heart failure patients without causing the kidney function failure,which is worthy of clinical promotion.关键词
托伐普坦/心力衰竭/心功能/肾功能Key words
tolvaptan/heart failure/cardial function/renal function分类
医药卫生
