中国药业Issue(7)：10-11,12,3.
喹硫平和利培酮治疗老年期痴呆精神行为障碍对照研究
Comparative Study on Quetiapine and Risperidone in Treatment of Mental and Behavioral Disorder in Senile Dementia Patients
袁刚 1杨通林 2曾昱 2叶文莉2
作者信息
- 1. 重庆市精神卫生中心女病区，重庆 401147
- 2. 重庆市长寿区精神病医院，重庆 401221
- 折叠
摘要
Abstract
Objective To study the efficacy and safety of quetiapine and risperidone for treating mental and behavioral symptoms in el-derly patients with dementia. Methods 55 inpatients with senile dementia were randomly assigned into two groups and treated with quetiapine(28 cases) or risperidone(27 cases) for an 8 - week treatment. The AD pathological behavior rating scale (BEHAVE - AD) and the Treatment Emergent Symptoms Scale(TESS) were used to evaluate the curative efficacy and the adverse reactions before treat-ment and at the end of 2nd, 4th, 8th week after treatment. The mini - mental state examination(MMSE) was used to evaluate the cogni-tive function. Results The total effective rates after treatment in the quetiapine group and the risperidone group were 82. 14% and 88. 89% respectively, no statistically significant difference was found between the two groups( P ﹥ 0. 05); the BEHAVE - AD scores at the end of 2nd week in the two groups began to be significantly decreased( P ﹤ 0. 01 or P ﹤ 0. 05), with no statistically significant dif-ference between the two groups; the BEHAVE - AD scores and the MMSE scores at the end of treatment had no statistically significant differences between the two groups( P ﹥ 0. 05 ); the occurrence rate of extrapyramidal symptoms(EPS) had statistically significant differ-ence between the two groups( P ﹤ 0. 01). Conclusion Quetiapine is as effective as risperidone for treating senile dementia, but has few-er extrapyramidal reactions than risperidone and would be more suitable for elderly patients.关键词
喹硫平/利培酮/老年期痴呆Key words
quetiapine/risperidone/senile dementia分类
医药卫生引用本文复制引用
袁刚,杨通林,曾昱,叶文莉..喹硫平和利培酮治疗老年期痴呆精神行为障碍对照研究[J].中国药业,2015,(7):10-11,12,3.
