摘要
Abstract
Objective To study the effect of Fexofenadine Hydrochloride Tablets combined with fluticasone propionate on the symptoms and serum levels of IFN - γ and IL - 4 in allergic rhinitis. Methods 86 patients with allergic rhinitis were randomly divided into the observation group and the control group, 43 cases in each group. The control group was given Fluticasone Propionate Nasal Spray for conducting the nasal spray therapy, while the observation group was added with oral Fexofenadine Hydrochloride Tablets. The clinical symptoms integral, clinical efficacy, change of serum IFN - γ and IL - 4 levels before and after treatment, and adverse reactions were ob-served and compared between the two groups. Results The clinical symptom scores in the observation group were 3. 84 ± 1. 65, which were significantly lower than those in the control group; the effective rate in the observation group was 90. 70% , which was significantly higher than 72. 09% in the control group; serum IFN - γ level was (56. 14 ± 10. 34) ng / mL, which was significantly lower than (78. 32 ± 12. 62) ng / mL that in the control group( P ﹤ 0. 05), serum IL - 4 level was (68. 61 ± 10. 26) ng / mL, which was significantly higher than (57. 40 ± 11. 83) ng / mL in the control group( P ﹤ 0. 01); there were no statistical difference in the adverse reactions be-tween the two groups( P ﹥ 0. 05) . Conclusion The combination medication scheme of Fexofenadine Hydrochloride Tablets and fluticas-one propionate for treating allergic rhinitis can effectively improve the clinical symptoms, improve immune imbalance status and increase the treatment effect.关键词
盐酸非索非那定片/丙酸氟替卡松/变应性鼻炎/临床疗效/免疫水平Key words
Fexofenadine Hydrochloride Tablets/fluticasone propionate/allergic rhinitis/clinical efficacy/immune level分类
医药卫生
