摘要
Abstract
Objective To explore the clinical effect of total parenteral nutrition(TPN) combined with alanyl glutamine (Gln) in the pa-tients with severe intestinal fistula. Methods By using the randomized controlled method, 48 patients with severe intestinal fistula were divided into the Gln group and the control group, 24 cases in each group. The TPN calories and the nitrogen amount in the two groups were basically consistent. The two groups all adopted the nutrient formula of high calories and high nitrogen amount for conducting the nutrition support. The Gln group added Gln 0. 4 g / (kg·d) on the basis of the above therapy. The blood sample collection was per-formed before treatment and on 5, 10 d after treatment for detecting the nutrition indexes, immune indexes, intestinal mucosal permeabili-ty, etc. The comparative and contrasting analysis was conducted. Results The two groups were improved in the aspects of nutrition and immunity, and the negative nitrogen balance was corrected; compared with the control group, the Gln group had better effects in the as-pects of the nutrition improvement, immunity enhancement and correcting the negative nitrogen balance after treatment( P ﹤ 0. 05); the WBC count was much lower( P ﹤0. 05); plasma Gln level was increased, the decrease of LPS and TNF - α was more significant( P ﹤0. 05). Conclusion Gln improves the intestinal barrier function in the patients with severe intestinal fistula, thus improves the patient's life quality.关键词
重症肠瘘/肠外营养/丙氨酰谷氨酰胺/肠道屏障功能Key words
severe intestinal fistula/parenteral nutrition/alanyl glutamine/intestinal barrier function分类
医药卫生
