摘要
Abstract
Objective To investigate the efficacy of ulinastatin for treating elderly severe acute pancreatitis(SAP)complicating intra-ab-dominal hypertension(IAH). Methods 62 elderly patients (> 60 years old ) with SAP complicating IAH were randomly divided into two groups,31 cases in each group. The control group was given the conventional treatment and the treatment group was additionally treated with 100 000 unit of ulinastatin per day. All patients were treated for 1 week. The clinical data were collected before and after treat-ment,including intra-abdominal pressure(IAP),tumor necrosis factor-α(TNF-α),interleukin(IL ) -6,plasma diamine oxidase(DAO), immunoglobulin A(IgA). The clinical effects of two groups were evaluated. Results The total effective rate of the treatment group was 93. 55%,which was significantly higher than 70. 97% in the control group( P < 0. 05). IAP,TNF-α,IL-6,DAO and IgA after 7 d treatment in the two groups were significantly improved compared with those before treatment( P < 0. 05). The ameliorative amplitude of those indexes in the treatment group was significantly higher than that in the control group( P < 0. 05). Conclusion Adding ulinastatin on the basis of conventional treatment can greatly improve the clinical effect of elderly SAP complicating IAH,and also improve the IAP and intestinal barrier function.关键词
乌司他丁/重症急性胰腺炎/腹内高压/老年Key words
ulinastatin/severe acute pancreatitis/intra-abdominal hypertension/elderly分类
医药卫生
