摘要
Abstract
Objective To study the acute toxicity and long-term toxicity of Yankang Oral Liquid in order to provide the scientific basis for its clinical safe use. Methods The acute toxicity test:on the basis of unable determining LD50,the maximum volume dose(1. 0 g/mL) was given to mice by intragastric gavage for 3 times within 24 h,and 7 d continuous observation was conducted;the long-term toxicity test:the rats were randomly divided into the control group,low,middle and high dose[0. 5,2. 5,5 mL/(kg·d)] groups respectively,the dose amount was equivalent to 1,5,10 times of clinical patients dosage. 5 male and female rats in each group were randomly killed af-ter 30 d. The tail venous blood was collected for determining the hemorheology and blood biochemical major indicators. The heart,liver, kidneys and lungs were performed the histopathological examination. Results The acute toxicity test indicated that the maximum tol-erance amount by gavage was at least equivalent to 300 times of clinical once treatment amount and had no toxic reactions. In the long-term toxicity test,the major indicators of body weight,hemorheology and blood biochemical in each dose group had no statistically significant differences with the control group,no obvious histopathological changes were found in the heart,liver,kidneys and lungs. Conclusion Yankang Oral Liquid is safe in clinical application.关键词
咽康口服液/急性毒性/长期毒性Key words
Yankang Oral Liquid/acute toxicity/long-term toxicity分类
医药卫生
