中国药业Issue(9)：12-13,2.
磷酸西格列汀治疗早期糖尿病肾病52例疗效观察
Observation on Effect of Sitagliptin Phosphate for Treating 52 Cases of Early Diabetic Nephropathy
郭全付 1毛焕东 1乌新春 1刘欣 1马新宇 1吴丽娜 1高书华1
作者信息
- 1. 河北省迁西县人民医院内四科，河北 唐山 064300
- 折叠
摘要
Abstract
Objective To observe the effect of sitagliptin phosphate in treating early diabetic nephropathy ( DN ) . Methods 105 patients with early diabetic nephropathy of type 2 diabetes mellitus ( T2DM ) were randomly divided into the sitagliptin phosphate group and the acarbose group. The sitagliptin phosphate group ( 52 cases ) was given oral Sitagliptin Phosphate Tablets, while the acarbose group ( 53 cases ) took oral Acarbose Tablets, the course of treatment was 48 weeks. The blood pressure ( BP ) , fasting plasma glucose ( FPG ) , glyco-sylated hemoglobin ( HbA1C ) , serum high sensitivity C-reactive protein ( hsCRP ) and change of urinary albumin excretion rate ( UAER ) before and after treatment were observed in the two groups. Results FPG and HbA1C in the two groups were significantly decreased. But the sitagliptin phosphate group was superior to the acarbose group in the aspects of reducing BP, hsCRP and UAER ( P < 0. 05 ) . Conclusion Sitagliptin phosphate decreases the glucose in T2DM patients with early DN, at the same time, also can reduce UAER and has the therapeutic effect on early DN.关键词
磷酸西格列汀/2型糖尿病/早期糖尿病肾病/尿白蛋白排泄率Key words
sitagliptin phosphate/type 2 diabetes mellitus/early diabetic nephropathy/urinary albumin excretion rate分类
医药卫生引用本文复制引用
郭全付,毛焕东,乌新春,刘欣,马新宇,吴丽娜,高书华..磷酸西格列汀治疗早期糖尿病肾病52例疗效观察[J].中国药业,2015,(9):12-13,2.
