摘要
Abstract
Objective To analyze the effect of levetiracetam for treating child epilepsy and its impact on the intelligence level. Methods 80 children patients with epilepsy treated by levetiracetam in the neurologic department of our hospital from January 2012 to January 2014 were selected. The cognitive function before and after 3, 6 months of treatment and the EEG epileptiform discharges situation after 3, 6 months of treatment were detected. The immune function was compared between before treatment and after 6-month treatment. At the same time the oc-currence situation of adverse reactions was recorded. Results The IQ, VIQ, PIQ, FIQ and short-term visual memory after 3, 6 months of treat-ment were significantly higher than those before treatment, moreover the various indexes after 6-month treatment were significantly higher than those after 3-month treatment, the differences were statistically significant( P < 0. 05). The remission rate after 6-month treatment was 81. 25%, which was significantly higher than 46. 25% after 3-month treatment with statistical difference( P < 0. 01) . The CD3+ and CD4+levels after 6-month treatment were significantly higher than those before treatment, the CD8+, IgG, IgA, IgM, and ICAM-1 levels were signifi-cantly lower than those before treatment, the differences were statistically significant( P < 0. 05). The occurrence rate of adverse reactions was 6. 25% and the symptoms disappeared after the appropriate reduction of drug dose. Conclusion The levetiracetam monotherapy has better clinical efficacy for treating various seizure types of epilepsy in children and can significantly improve EEG and intelligence with fewer adverse reactions, which is worthy of promotion.关键词
左乙拉西坦/疗效/癫痫/智力Key words
levetiracetam/monotherapy/epilepsy/intellectual level分类
医药卫生
