摘要
Abstract
Objective To explore the clinical effect of umbilical cord mesenchymal stem cells ( UC-MSC ) combined with rituximab in the treatment of systemic lupus erythematosus ( SLE ) and to summarize the nursing experience. Methods 30 cases of SLE in our hospi-tal from January 2013 to July 2014 were selected and randomly divided into the control group and the observation group, 15 cases in each group. The control group adopted the therapy of UC-MSC infusion, while the observation group was given the therapy of UC-MSC combined with rituximab. The two groups were given the appropriate nursing measures. Results The SLE disease activity index ( SLEDAI ) scores after 3-week and 6-month treatment in the two groups were significantly decreased compared with before treatment ( P < 0. 05 ) , moreover the decrease after 6-month treatment was more obvious than that after 3-week treatment ( P < 0. 05 ) , but the difference at the same time point between the two groups had no statistical significance ( P > 0. 05 );the IFN-gamma and IL-4 levels after treatment were significantly decreased compared with before treatment ( P < 0. 05 ) , moreover the decrease in the observation group was more significant ( P < 0. 05 ) . The IL-6, IL-8 and IL-10 levels after treatment were significantly decreased compared with before treatment ( P < 0. 05 ) , moreover the decrease after 6-month treatment in the same group was more significant than that after 3-week, but the difference between the two group had no statistical significance ( P > 0. 05 ) . The occurrence rate of adverse reactions after treat-ment had no statistical difference between the two groups ( P > 0. 05 ) . Conclusion UC-MSC combined with rituximab for treating SLE has the targeted effect and good safety, can effectively eliminate pathological B cells, reduce the release of inflammatory cytokines and improve the body ’ s immune inflammation status. The meticulous nursing on patients is also a key for successful treatment.关键词
脐带间充质干细胞/利妥昔单抗/系统性红斑狼疮/临床疗效/护理Key words
UC-MSC/rituximab/systemic lupus erythematosus/clinical efficacy/nursing分类
医药卫生
