中国药业Issue(12)：44-45,46,3.
静脉与关节腔内使用氨甲环酸对全膝关节置换术失血量的影响比较
Comparison of Effects on Intravenous and Intra-Articular Cavity Injection of Tranexamic Acid on Blood Loss Volume in Total Knee Arthroplasty
蒋华 1颜宇 2马红兵 1曾勇 1徐兵 1王俊瑞1
作者信息
- 1. 四川省成都市第二人民医院骨科，四川 成都 610017
- 2. 四川大学附属华西医院骨科，四川 成都 610000
- 折叠
摘要
Abstract
Objective To compare the effects and operative safety of intravenous drip and intra-articular cavity local injection of tranexamic acid on controlling blood loss volume in total knee arthroplasty. Methods Totally 73 patients with total knee arthroplasty treated in the hospital from January 2012 to October 2014 were randomly divided into the intravenous drip group(IVTA,contorl group, 40 cases) and the intra-articular use group(IATA,treatment group,33 cases). The patients in the control group used intravenous tranexamic acid 10 mg/kg,with the maximum dose 1. 0 g during the anesthetic induction period,while the patients in the treatment group were intra-articularlly injected by tranexamic acid 1 g at the finishing of articular capsule suture and before relaxing the tourni-quet. Results The postoperative total blood loss volume in the control group was significantly decreased compared with that in the treatment group( P < 0. 05);there were no statistically significant differences in the postoperative coagulation function(PT,APTT,INR) and the incidence rate of deep venous thrombosis(DVT) between the two groups( P ? 0. 05). Conclusion The intra-articular cavity injection of tranexamic acid is a safer scheme for effectively controlling postoperative blood loss volume without increasing the occur-rence probability of postoperative DVT.关键词
全膝关节置换术/氨甲环酸/局部注射/静脉滴注/凝血功能/深静脉血栓Key words
total knee arthroplasty/tranexamic acid/local injection/intravenous drip/coagulation function/deep venous thrombosis分类
医药卫生引用本文复制引用
蒋华,颜宇,马红兵,曾勇,徐兵,王俊瑞..静脉与关节腔内使用氨甲环酸对全膝关节置换术失血量的影响比较[J].中国药业,2015,(12):44-45,46,3.
