中国药业Issue(13)：8-9,10,3.
地西泮合并心理干预治疗酒依赖伴抑郁35例疗效评价
Diazepam Combined with Psychological Intervention for Treating Alcohol Dependence Complicating Depression in 35 Cases
摘要
Abstract
Objective To observe the clinical efficacy of diazepam combined with psychological intervention in the treatment of alcohol dependence complicating depression. Methods 70 patients with alcohol dependence complicating depression were randomly assigned to the intervention group treated by diazepam combined with the psychological intervention ( intervention group ) and single diazepam treat-ment group ( control group ) , 35 cases in each group. The treatment lasted for 8 weeks. The curative effects and adverse reactions were assessed before treatment and at the end of 1, 2, 4, 8 weeks by adopting the Hamilton depression scale ( HAMD ) , Hamilton anxiety scale ( HAMA ) , clinical general impression ( CGI ) and treatment emergent symptom scale ( TESS ) . Results The scores of HAMD, HAMA and CGI after 1, 2, 4, 8 weeks of treatment in both groups were significantly lower than before treatment ( P ﹤ 0. 05 ) , moreover which at var-ious time points in the intervention group were significantly lower than those in the control group ( P ﹤ 0. 05 ) The effective rate in the intervention group was 94. 29%, which was significantly higher than 74. 29% in the control group ( P ﹤ 0. 05 ); the incidence rate of adverse reactions in the intervention group was 25. 71%, which was significantly lower than 60. 00% in the control group, the difference was statistically significant ( P ﹤ 0. 05 ) . Conclusion Diazepam combined with psychological intervention has better effect with rapid on-set and less adverse reactions for treating alcohol dependent complicating depression than single use of diazepam.关键词
地西泮/心理干预/酒依赖Key words
diazepam/psychological intervention/alcohol dependence分类
医药卫生引用本文复制引用
程宇,余成民,李宁佳,冯婧,李薇..地西泮合并心理干预治疗酒依赖伴抑郁35例疗效评价[J].中国药业,2015,(13):8-9,10,3.基金项目
2013年川北医学院科研发展计划，项目编号CBY13－B－QN15。 （）
