摘要
Abstract
Objective To retrospectively analyze the clinical manifestations, influencing factors of drug fever induced by piperacillin-tazobactam to provide reference for timely and accurately judging drug fever and avoiding excessive, combination or blindly upgrade use of antibacterial drugs during anti-infective treatment process. Methods Totally 30 cases of piperacillin-tazobactam induced drug fever collected in these 3 hospitals from September 2013 to September 2014 were performed the retrospectively statistical analysis on the medication situation, clinical manifestaions, laboratory detection and treatment modes. Results The majority of piperacillin-tazobactam in-duced drug fever occurred on 7-14 d of consecutive medication, the unit cumulative amount was generally between 1. 3- 2. 7g/kg. All patients had a fever during infusion or within some hours after infusion, and most of them had a hyperpyrexia of 38. 5-40 ℃, in which most patients had normal blood leukocytes and neutrophils and normal or mildly elevated CRP, and eosinophils in some pa-tients were mildly increased;some patients were accompanied by chills, shivering, fatigue, most patients had no other obvious uncomfort-able symptoms. The temperature of the patients would drop to the normal level after withdrawal drug within 24-48 h. In generally clin-icians had little understanding and pay attention to drug-fever, which was not conducive to the correct diagnosis of drug fever. Conclusion Piperacillin-tazobactam induced drug fever has no specific diagnostic criteria, but analyzing the fever time, medica-tion time and unit cumulative amount of drug, and combining with the comprehensive consideration of blood routine, CRP and other lab-oratory indexes can provide beneficial reference for judging drug fever. Clinicians should pay attention to the comprehensive judgment and screening the possibility of drug fever for the patients with infectious symptoms improvement by piperacillin-tazobactam anti-in-fective therapy appearing fever again. Clinical pharmacists should make full use of the professional advantages, and play a positive role in assisting clinicians in the diagnosis of drug fever and promoting rational drug use in clinic.关键词
哌拉西林他唑巴坦钠/药物热/临床分析Key words
piperacillin-tazobactam/drug fever/clinical analysis分类
医药卫生
