中国药业Issue(14)：30-31,32,3.
金钱草胶囊中槲皮素人体药代动力学研究
In Vivo Pharmacokinetic of Quecertin in Jinqiancao Capsule
摘要
Abstract
Objective To study the in vivo pharmacokinetics of quecertin in Jinqiancao Capsule to provide reference for clinic. Methods Siz healthy volunteers were given a single oral dose of Jinqiancao Capsule 1. 6 g. Then the serum concentration of quercetin was determined by HPLC. The pharmacokinetic parameters were calculated by the DAS pharmacokinetic program. Results The main pharmacokinetic parameters of quercetin for oral Jinqiancao Capsule were as follows:α was 1. 056,β was 0. 704,Ka was 2. 045/h,t1 /2βwas 0. 985 h,Tmaz was 3 h,Cmaz was 2. 308 85 mg/L,CL/ F was 271. 179 L/h,AUC0 -t was 5. 875 mg/(L·h)and AUC0 -∞ was 5. 900 mg/ (L·h). Conclusion The pharmacokinetic parameters of Chinese medicine Lysimachia christinae Hance conform to a two-compartment model( Wi=1/ C,AIC=9. 043).关键词
金钱草胶囊/槲皮素/高效液相色谱法/药代动力学Key words
Jinqiancao Capsule/quercetin/HPLC/pharmacokinetics分类
医药卫生引用本文复制引用
王洪锐,陈玩珊,冯雪科,吴毓朝,原文鹏..金钱草胶囊中槲皮素人体药代动力学研究[J].中国药业,2015,(14):30-31,32,3.基金项目
广东省中医药局建设中医药强省科研课题，项目编号20131030；深圳市科技计划项目（医疗卫生类），项目编号201203293。 （）
