中国医药科学Issue(5)：9-11,3.
含RGD修饰的丹参酮ⅡA多级靶向纳米粒的质量评价
Preparation and characterization of TSⅡA-loaded mPEG-PLGA-PLL-cRGD nanoparticles
摘要
Abstract
Objective To prepare and evaluate the novel polymeric nanoparticles containing Tanshinon Ⅱ A (TS Ⅱ A-mPEG-PLGA-PLL-cRGD NPs, TNP). Methods TNP was prepared by using a emulsion/solvent evaporation method. The size, shape, zeta, drug loading, encapsulation efficiency, and release of these nanoparticles were studied in vitro. Results TNP were of uniform size with an average particle size of 190nm and zeta potential of 4.3mV.The encapsulation efficiency was (94.12±5.20)%and the drug load was (2.05±0.12)%. It showed that the release curve of TNP was prolonged. Conclusion TNP was stable and had a slow-releasing and tumor targeting effect.关键词
丹参酮ⅡA/载药纳米粒/RGD/缓释/表征Key words
TanshinoneⅡA/Nanoparticles/cRGD/Slow-release/Characterization分类
化学化工引用本文复制引用
王炎,宋大迁,王青,范忠泽,李琦..含RGD修饰的丹参酮ⅡA多级靶向纳米粒的质量评价[J].中国医药科学,2014,(5):9-11,3.基金项目
国家自然科学基金资助项目（81001594）；上海市科学技术委员会科研计划项目（114119a9500）；上海市科学技术委员会科研计划项目（11nm0504500）；上海市卫生局青年科研项目（2009Y091）。 （）
