中国医药科学Issue(5)：25-28,4.
乌司他丁对脓毒症致大鼠急性肾损伤肾功能及尿相关指标的影响
Protective effects of ulinastatin on acute kidney injury in rats with sepsis
摘要
Abstract
Objective To investigate the effects of ulinastatin on acute kidney injury in rats with sepsis. Methods Fifty-five healthy male sprague-dawley rats were randomly divided into 3 groups: normal control, model group, ulinastatin group.The rat models of sepsis were established by caecal ligation and puncture(CLP).In treatment groups, rats were treated with ulinastatin through caudalis injection after CLP surgery.Each group was divided into 1, 6, 12, 24, 48 hour subgroups with 5 rats. Rats were sacrificed and tissue samples including kidney and blood samples were collected.The kidney function,urine level of kidney injury molecule-1(KIM-1), neutrophil gelatinase lipocalin(NGAL) and interleukin-18(IL-18) were measured.Results Compared with CLP model group, renal function, the levels of KIM-1, NGAL and IL-18 in urine, significantly decresed in Ulinasta group(P < 0.05). Conclusion Ulinasta can improving renal function duringAKI in the rat model of sepsis.关键词
乌司他丁/脓毒症/急性肾损伤/尿相关指标Key words
Ulinastatin/Sepsis/Acute kidney injury/Urine biological mark分类
医药卫生引用本文复制引用
曹波,张琳琳,柴春香,赵学兰,张培荣,陈学勋..乌司他丁对脓毒症致大鼠急性肾损伤肾功能及尿相关指标的影响[J].中国医药科学,2014,(5):25-28,4.基金项目
山东省潍坊市卫生局科研项目[（2013）年第078号]。 （）
