摘要
Abstract
Objective To investigate the expression and significance of JAM-1 in the endometrial carcinoma tissues with different myometrial invasion depth. Methods Seventy-three patients with endometrial carcinoma were selected, of which 18 patients were without myometrial invasion, 28 patients had superficial invasion and 17 patients had deep invasion. The immunohistochemistry was used to detect the expression situation of JAM-1 in the three groups with no superficial and deep invasion. Results JAM-1 expressed in the cancer cells of endometrial carcinoma and cell membrane and cytoplasm of glandular cells. As the depth of myometrial invasion increased, the expression of JAM-1 weakened significantly, with statistically significant differences(P < 0.05). Conclusion In endometrial carcinoma, the expression of JAM-1 and invasion depth of cancer cells are negatively correlated, suggesting that JAM-1 may be associated with the invasion of endometrial carcinoma.关键词
子宫内膜癌/连接黏附分子1/肌层浸润Key words
Endometrial carcinoma/Junctional adhesion molecule 1/Myometrial invasion分类
医药卫生
