摘要
Abstract
Dalldorf found and described what was named Coxsackie virus later in the children of Coxsackie New York of America in 1948. The disease caused by Coxsackie virus was named as hand-foot-and-mouth disease(HFMD) by Alsop in 1960. Later the disease was found prevalent in different areas worldwide. China first reported HFMD in 1980 and Guangxi first discovered and reported this disease in 1989. Since HFMD was classified as a national legal class C infectious disease in 2008, Guangxi had studied the pathogen genotypes of HFMD in detail and found that enterovirus 71(EV71) accounted for 41.70% and coxsackievirus A16(CoxA16) accounted for 8.50%. Meanwhile, the EV71 separated in Guangxi was highly homologous with the EV71 strains prevalent in other provinces and both belonged to the C4b branch of C4 gene subtype. Data show that HFMD presents a growth and decline trend of natural prevalence. Although the study of HFMD vaccines has achieved extensive progress, but their field application is still facing multiaspect challenges.关键词
手足口病/柯萨奇病毒/肠道病毒A16型/肠道病毒EV71型Key words
Hand-foot-and-mouth disease/Coxsackie virus/Intestinal virus type A16/Intestinal virus EV71 type分类
医药卫生
