中国医药科学Issue(8)：20-22,38,4.
白细胞介素-11雾化吸入治疗鼻咽癌同期放化疗导致口腔黏膜炎的疗效观察
Efficacy of interleukin-11 inhalation treatment of oral mucositis caused by concurrent chemo-radiotherapy of nasopharyngeal carcinoma
杨乐伟 1孙玉勤 1陈嘉洛 1杨光伟1
作者信息
- 1. 中山大学附属第五医院肿瘤放疗科，广东珠海519000
- 折叠
摘要
Abstract
Objective To investigate the clinical efficacy of interleukin-11(IL-11) inhalation treatment of oral mucositis caused by concurrent chemo-radiotherapy of nasopharyngeal carcinoma and to provide a new method for the treatment of oral mucositis caused by concurrent chemo-radiotherapy of nasopharyngeal carcinoma. Methods 84 patients were selected in the oncology of our hospital during April 2010 to June 2013, which were diagnosed with newly nasopharyngeal cancer. The changes of oral mucositis were observed before the drug inhalation and 3-7 weeks after radiotherapy, and the healing of oral mucositis were also observed one week after the end of radiotherapy. And then the clinical efficacies of interleukin-11(IL-11) inhalation treatment of oral mucositis caused by concurrent chemo-radiotherapy of nasopharyngeal carcinoma were analyzed comparatively. Results In the first two weeks, the patients of both two groups existed oral mucositis after radiotherapy, but compared with the control group, oral mucositis classification in the observation group had no change significantly, but with the continued increase in radiation dose and radiation therapy, the degree of the patients in the observation group were mainly grade Ⅰ - Ⅱdegree, and those in the control group were mainly Ⅱ - Ⅲ degree. Between two groups of patients found the oral mucosa of patients in the observation group compared with the extent of reaction the control group was significantly increased(P < 0.05); 1 week after the end of radiotherapy, the effective rate was 90.5% in the observation group to the total oral mucositis treatment, compared with the control group was significantly higher(x2=27.064,P=0.000). Conclusion IL-11 inhalation can effectively reduce the degree of oral mucositis caused by nasopharyngeal concurrent chemo-radiotherapy, and has a facilitating role for the treatment of oral mucositis.关键词
白细胞介素-11/鼻咽癌/放射治疗/口腔黏膜炎/药物疗法Key words
Interleukin-11/Nasopharyngeal carcinoma/Radiation therapy/Oral mucositis/Drug therapy分类
医药卫生引用本文复制引用
杨乐伟,孙玉勤,陈嘉洛,杨光伟..白细胞介素-11雾化吸入治疗鼻咽癌同期放化疗导致口腔黏膜炎的疗效观察[J].中国医药科学,2014,(8):20-22,38,4.
