中国医药科学Issue(12)：18-21,4.
乳腺癌组织中SPARC和Her-2的表达
SPARC and Her-2's expression in breast cancer tissue
孙孝媛 1于国华 2张居民3
作者信息
- 1. 潍坊医学院研究生院，山东潍坊261041
- 2. 山东省潍坊市人民医院肿瘤内科，山东潍坊261041
- 3. 山东省潍坊市人民医院病理科，山东潍坊261041
- 折叠
摘要
Abstract
Objective To investigate SPARC and Her-2 in breast cancer tissue and its relationship with clinicopathological parameters. Methods Immunohistochemistry was used to detect the expression of 70 cases of breast cancer and 20 cases of breast fibroadenoma SPARC and Her-2's. Results SPARC overexpression in breast cancer rates between stromal cells 68.6% (48/70) was significantly higher than the rate of tumor cells expressing 37.1%(26/70) (P<0.05);mammary stromal cells SPARC expression rate of cancer in 68.6%(48/70) was significantly higher than the expression of breast fibroadenoma 40.0%(8/20) (P < 0.05); in lymph node metastasis,TNM stage ⅢSPARC expression in breast cancer rates rise(P < 0.05).Her-2 was mainly expressed on the membrane of breast cancer cells,high expression rate in breast cancer cells in 45.7%(32/70) was significantly higher than the expression of breast fibroadenoma 10.0% (2/20) (P<0.05). Her-2 expression rate of lymph node metastasis than those without lymph node metastasis high(P<0.05). Conclusion Breast Cancer SPARC,high expression of Her-2 breast cancer i ncidence,progression,metastasis and prognosis.关键词
SPARC/Her-2/乳腺肿瘤Key words
SPARC/Her-2/Breast neoplasms分类
医药卫生引用本文复制引用
孙孝媛,于国华,张居民..乳腺癌组织中SPARC和Her-2的表达[J].中国医药科学,2014,(12):18-21,4.
