中国医药科学Issue(16)：12-15,22,5.
不同剂量布地奈德混悬液氧气雾化对慢性阻塞性肺疾病的疗效比较
Comparison of the efficacy of different dose nebulized budesonide in treatment of chronic obstructive pulmonary disease
摘要
Abstract
ObjectiveTo investigate the efficacy of different doses budesonide on chronic obstructive pulmonary disease, aimed at improving the therapeutic effect.Methods420 stable COPD patients and 330 cases of acute COPD patients treated in our hospital from 2011.04 to 2013.11 were enrolled. the stable COPD patients were divided into moderate doses group, low-dose group and the control group . The AECOPD patients were divided into high-dose group, middle dose group, generally dose group and the control group. Comparative analysis of the therapeutic effect, pulmonary function and quality of life in different groups.Results The dyspnea scores of stable patients in moderate-dose group and low-dose group were significantly improved compared with control group (P<0.05). the difference of FEV1 and FEV1/FVC% in medium- dose group, low dose group and the control group was statistically significant after treatment (P<0.05) . The difference of QOL scores was statistically significant in moderate dose group, low -dose group and the control group (P<0.05). The lung function of AECOPD patients in three groups showed significant improvement after treatment of 5 days and 10 days (P<0.05).Conclusion For stable COPD patients, small dose of budesonide was more effective, without significant side effects, can be widely used clinical. For AECOPD, large doses of budesonide inhalation can make faster and better improvement in lung function. And it is safe and effective in clinical application.关键词
布地奈德/慢性阻塞性肺疾病/肺功能Key words
Budesonide/Chronic obstructive pulmonary disease/Lung function分类
医药卫生引用本文复制引用
王梦芝,佘德宇,卢淑玲..不同剂量布地奈德混悬液氧气雾化对慢性阻塞性肺疾病的疗效比较[J].中国医药科学,2014,(16):12-15,22,5.基金项目
广东省东莞市医疗卫生单位科技计划一般项目（201110515022198）。 （）
