中国医药科学Issue(16)：26-29,4.
高脂饮食小鼠脂肪组织中PAI-1、FOXC2及FOXO1表达的研究
Study of expression of PAI-1, FOXC2 and FOXO1 in adipose tissue of mice with high fat diet
摘要
Abstract
Objective To study the expression level of PAI-1, FOXC2 and FOXO1 in high fat diet of visceral fat and subcutaneous fat tissue,and to investigate the mechanism of different types of obesity.Methods 20 mouse were randomLy divided into control group and high fat group, and given normal diet and high fat diet for 12 weeks. Serum PAI-1,the expression level of PAI-1, FOXC2 and FOXO1 mRNA in epididymal tissue and subcutaneous fat were determined. Results The body weight, serum PAI-1 levels of high fat group were significantly higher than those of the control group. Within the group, PAI-1,FOXC2, mRNA expression of mouse epididymal adipose tissue were significantly higher than those of the subcutaneous adipose tissue, and the expression of FOXO1mRNA of mouse epididymal adipose tissue was significantly lower than that of subcutaneous adipose tissue, with statistical significance difference. Conclusion Expression levels of serum PAI-1 are different between normal weight mice and obese mice,and expression of fat PAI-1, FOXC2and FOXO1 in visceral fat and subcutaneous are also different. This difference may be one of the mechanisms of different types of obesity.关键词
血浆纤溶酶原激活物抑制物-1/FOXC2/FOXO1Key words
Plasminogen activator inhibitor -1/FOXC2/FOXO1分类
医药卫生引用本文复制引用
刘亚莉,易佳丽,刘剑辉,牛丽凤..高脂饮食小鼠脂肪组织中PAI-1、FOXC2及FOXO1表达的研究[J].中国医药科学,2014,(16):26-29,4.基金项目
辽宁省教育厅科学研究一般项目（L2011246）。 （）
