中国医药科学Issue(17)：9-11,3.
IL-28B单核苷酸基因多态性与CHB干扰素疗效的相关性
Correlation between IL-28B single nucleotide polymorphism and effectiveness of interferon in CHB
摘要
Abstract
ObjectiveTo explore the correlation between IL-28B single nucleotide polymorphism and effectiveness of interferon in chronic hepatitis B (CHB).Methods 300 cases of HBeAg positive patients with CHB were selected, and given pegylated interferon alpha (Peg-INF-a) standard treatment. The IL-28B SNP rs12979860 and IL-28B SNP rs8099917 genotyping were tested with PCR method after treatment of 48 weeks.Results HBV DNA quantification, ALT and AST levels after treatment decreased significantly compared with before treatment (P<0.05), HBeAg metastasis rate was 53.13%, response rate after a year of follow-up was 49.44%; the differences were no statistical significant in genotype CC, CT, TT distribution of IL-28B SNP rs12979860 and C, T frequency of allele between Peg-INF-a responder patients and non Peg-INF-a responder patients (P>0.05), the differences were statistical significant in genotype TT, TG distribution of IL-28B SNP rs8099917 and T, G frequency of allele (P<0.05). ConclusionIL-28B SNP rs8099917 may impact the formation of response to interferon treatment, including increased frequency of allele G could prompt the success of the interferon response, thus detecting IL-28B SNP rs8099917 to effectiveness of interferon treatment in CHB patients has certain predictive value.关键词
IL-28B/单核苷酸基因多态性/慢性乙型肝炎/干扰素Key words
IL-28B/Single nucleotide genetic polymorphisms/Chronic hepatitis B/Interferon分类
医药卫生引用本文复制引用
丁慧俊..IL-28B单核苷酸基因多态性与CHB干扰素疗效的相关性[J].中国医药科学,2014,(17):9-11,3.基金项目
广东省东莞市科技计划项目（201110515001084）。 （）
