中国医药科学Issue(18)：23-25,33,4.
内皮型一氧化氮合酶Glu298Asp基因多态性与老年原发性高血压微量白蛋白尿的关系
Association between endothelial nitric oxide synthase Glu298Asp genetic polymorphisms and microalbuminuria in aged persons with essential hypertension
王健 1戴云湘 1郑玮 1毛拥军2
作者信息
- 1. 青岛市胶州中心医院急诊内科，山东青岛266300
- 2. 青岛大学附属医院特需保健科，山东青岛266003
- 折叠
摘要
Abstract
Objective To investigate the association between endothelial nitric oxide synthase (eNOS)gene Glu298Asp polymorphisms and microalbuminuria(MAU) in elderly patients with essential hypertension(EH). Methods 24-hour microalbuminuria the whole day was quantified in 202 elderly patients with EH,but without dominant proteinuria. and eNOS gene Glu298Asp polymorphisms was assayed by gene chip technology.According to 24-hour microalbuminuria,patients were divided into two groups:microalminuria group(MAUgroup) and normoalbuminuria group(NAUgroup).The allele and genotype frequency distributions were compared between the two groups. Results In the two groups there are different distribution frequencies beteen G allele and T allele.So was among the three genotypes(GG,GT and TT).The frequencies of T allele and the genotypes with T allele in the MAU group were remarkably higher than the NAU group(x2=6.62, P<0.01;x2=7.29, P<0.01).Mutation of T allele caused a high relative ratio risk ratio of MAU in elderly patients with hypertension(OR=2.361,95%CI=1.256~4.437). Conclusion T alllele is one suscepitibity gene of elderly hypertensive patients with MAU.Elderly hypertensive patients carrying T allele are susceptible to MAU..关键词
内皮型一氧化氮合酶/基因多态性/老年原发性高血压/微量白蛋白尿Key words
Endothelial nitric oxide synthase/Genetic polymorphism/Essential hypertension in elderly patients/Microalbuminuria分类
医药卫生引用本文复制引用
王健,戴云湘,郑玮,毛拥军..内皮型一氧化氮合酶Glu298Asp基因多态性与老年原发性高血压微量白蛋白尿的关系[J].中国医药科学,2014,(18):23-25,33,4.
