中国医药科学Issue(20)：13-16,4.
右美托咪定对非体外循环冠状动脉旁路移植术中患者血流动力学的影响
The effect of dexmedetomidine on hemodynamics in patients with off pump coronary artery bypass grafting
摘要
Abstract
Objective To investigate the effect of dexmedetomidine on hemodynamics in patients with off pump coronary artery bypass grafting. Methods Three hundred and sixteen patients undergoing off pump coronary artery bypass grafting were randomly divided into two groups (n=158): control group(group A) and dexmedetomidine group(group B). After induction of anesthesia, a loading dose of dexmedetomidine 1μg/(kg·10min) was injected intravenously over 10 minutes, followed by infusion at 0.5μg/(kg·h) until the end of operation in group D. While the equal volume of normal saline was given in group C. Heart rate, central venous pressure, mean arterial pressure, mean pulmonary arterial pressure, pulmonary artery wedge pressure, cardiac output, systemic vascular resistance and pulmonary vascular resistance were recorded and calculated at the time before anesthesia induction (T0), before skinincision (T1), cutting skin (T2), sternotomy (T3), before bypass (T4), bypassing (T5), and the end of operation (T6). Results There was no significant difference in sex, age, weight, height, heart function, operation time and anesthetic time (P > 0.05). In group A, heart rate, mean arterial pressure increased significantly (P < 0.05). Compared with group A, heart rate, mean arterial pressure, mean pulmonary arterial pressure, systemic vascular resistance and pulmonary vascular resistancethe were significantly lower in group B (P < 0.05). Conclusion During off pump coronary artery bypass grafting, dexmedetomidine infused at 0.5μg/(kg·h) after a loading dose of 1μg/(kg·10min) is useful in maintaining hemodynamics stable.关键词
右美托咪定/非体外循环/冠状动脉旁路移植/血流动力学Key words
Dexmedetomidine/Off pump/Coronary artery bypass grafting/Hemodynamics分类
医药卫生引用本文复制引用
刘超,程兆云,宋先荣,李晓慧,刘富荣,丁付燕,王晓航..右美托咪定对非体外循环冠状动脉旁路移植术中患者血流动力学的影响[J].中国医药科学,2014,(20):13-16,4.基金项目
国家临床重点专科建设项目（卫办医政函[2011]873号）。 （）
