中国医药科学Issue(20)：136-138,3.
2型糖尿病肾病患者血清VEGF、IL-6及TNF-α水平的检测与意义
Detection of the level and its significance of VEGF, IL 6 and TNF-αin patients with type 2 diabetic nephropathy
吴琼皎1
作者信息
- 1. 河南省三门峡市中心医院 河南科技大学附属三门峡市中心医院肾内科，河南三门峡472000
- 折叠
摘要
Abstract
Objective To study the detection of the level and its clinical significance of vascular endothelial growth factor(VEGF). interleukin-6(IL-6) and tumor necrosis factor-a(TNF-α) in patients with type 2 diabetic nephropathy(DN). Methods The levels of VEGF, IL-6and TNF-α in 40 patients with DN, 36 patients diagnosed simply type 2 diabetes mellitus(DM) and 38 healthy persons (healthy controls) were radioimmunologically examined. Results The level of VEGF, IL-6 and TNF-α in the DN group were markedly lower than those in the healthy group(P < 0.01) and the simply type 2 DM group(P < 0.01). Conclusion The VEGF, IL-6 and TNF-α were important inflammatory mediators in the development of the DN, high levels of VEGF, IL-6 and TNF-α may play important roles in the occurrence and development of the type 2 diabetes mellitus and diabetic complications, detecting the level changes can be used as references for clinical diagnosis of type 2 diabetic nephropathy.关键词
2型糖尿病肾病/VEGF/IL-6/TNF-αKey words
Type 2 diabetic nephropathy/VEGF/IL-6/TNF-α分类
医药卫生引用本文复制引用
吴琼皎..2型糖尿病肾病患者血清VEGF、IL-6及TNF-α水平的检测与意义[J].中国医药科学,2014,(20):136-138,3.
