中国医药科学Issue(20)：196-198,206,4.
冠心病老年男性患者雄激素受体CAG基因多态性重复数影响发病风险的临床研究
Study of androgen receptor CAG repeat polymorphism and coronary artery disease in elderly men
马和平 1刘霞 1刘越童 1袁慧芸1
作者信息
- 1. 广东省东莞市寮步医院内科，广东东莞523400
- 折叠
摘要
Abstract
Objective To investigate the relationship of androgen receptor CAG repeat polymorphism and coronary artery disease in elderly men. Methods 86 cases of coronary artery disease patients were randomly selected as the observation group,and 100 cases of medical non coronary heart disease were selected as control group,who were treated in our hospital department of cardiovascular internal medicine. Results Investigation of androgen receptor CAG repeat sequence number of the two groups of subjects peripheral was determined by polymerase chain reaction (PCR) and direct sequencing method.Risk factors of coronary heart disease were analyzed by multivariate logistic regression analysis.The observation group and the control group were no significant difference in the four indicators of age,BMI,TT, E2(P > 0.05),but the hypertension,diabetes,hyperlipidemia,family history of diabetes,family history of coronary heart disease,CAG repeat numbers of < 22,CAG repeat number ≥ 22 of two groups had the obvious difference with statistical significance(P < 0.05).Smoking,hypertension,diabetes,hyperlipidemia,family history of coronary heart disease,CAG repeat number<22 were risk factors for coronary heart disease.Coronary heart disease risk of CAG repeat numbers < 22 was 4.421 times greater than that of CAG repeat numbers ≥ 22. Conclusion There are many risk factors of CHD.Androgen receptor gene CAG polymorphism repeat number < 22 is one of the major risk factors of coronary heart disease.关键词
雄激素受体/基因多态性/冠心病/发病风险Key words
Androgen receptor/Gene polymorphism/Coronary artery disease/Onset risk分类
医药卫生引用本文复制引用
马和平,刘霞,刘越童,袁慧芸..冠心病老年男性患者雄激素受体CAG基因多态性重复数影响发病风险的临床研究[J].中国医药科学,2014,(20):196-198,206,4.
