中国医药科学Issue(23)：30-33,180,5.
联合检测蛋白ERCC1、Rad51和P53的表达与预测晚期非小细胞肺癌铂类药物化疗疗效的相关性研究
Correlation study on test the expression of ERCC1,Rad51 and P53 protein with the effect of Platinum drugs chemotherapy for late non-small cell lung cancer
许柏松 1冯耘2
作者信息
- 1. 合肥市第二人民医院呼吸科，安徽合肥230000
- 2. 上海交通大学医学院附属瑞金医院，上海200025
- 折叠
摘要
Abstract
Objective To test the expression of ERCC1,Rad51 and P53 protein in late non-small cell lung cancer and explore the clinical significance and the correlation with the effect of Platinum drugs chemotherapy. Methods The pathology specimens of 68 patients with late non-small cell lung cancer in our hospital from June 2012 to June 2013 were collected,used immunofluorescence histochemical staining method to test the expression of ERCC1,Rad51 and P53 in pathology specimens of late non-small cell lung cancer and peripheral lymphoid cells,the correlation between the expression in late non-small cell lung cancer and peripheral lymphoid cells was observed.Patients were treated by platinum standard chemotherapy regimens for 2-4weeks, the correlation between the expression of ERCC1,Rad51 and P53 with effect of Platinum drugs chemotherapy was evaluated. Results The positive rate (42.6%、35.3% and 45.6% respectively)and negative rate(33.8%、27.9% and 38.2% respectively)of ERCC1,Rad51 and P53 protein in late non-small cell lung cancer and peripheral lymphoid cells were same,there was a significant positive correlation(all P < 0.05).There was no significant of the expression of ERCC1,Rad51 and P53 in age/Sex,TNM stage and pathological types(P<0.05).The total effective rate of patients with ERCC1 positive expression after platinum drugs chemotherapy was 41.2% and significant lower than the effective rate(73.9%) of patients with ERCC1 negative expression(P<0.05);The total effective rate of patients with Rad51 positive expression after platinum drugs chemotherapy was 33.3% and significant lower than the effective rate(63.2%) of patients with Rad51 negative expression(P < 0.05);The total effective rate of patients with P53positive expression after platinum drugs chemotherapy was 29.0% and significant lower than the effective rate(58.3%) of patients with P53 negative expression(P < 0.05). Conclusion Test the expression of ERCC1,Rad51 and P53 protein in peripheral lymphoid cells of patients with late non-small cell lung cancer and explore can reflect the expression in the cancer tissue very well,the effect of Platinum drugs chemotherapy for patients with ERCC1 negative expression is more better.There has a negative correlation between the expression of ERCC1,Rad51 and P53 protein between the effect of Platinum drugs chemotherapy.关键词
晚期非小细胞肺癌/ERCC1/Rad51/P53/铂类药物/有效率/相关性Key words
Late non-small cell lung cancer/ERCC1/Rad51/P53/Platinum drugs/Effective rate/Correlation分类
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许柏松,冯耘..联合检测蛋白ERCC1、Rad51和P53的表达与预测晚期非小细胞肺癌铂类药物化疗疗效的相关性研究[J].中国医药科学,2014,(23):30-33,180,5.
