中国医药科学Issue(1)：44-47,4.
不同剂量三氧化二砷单独及联合顺铂对人宫颈癌移植瘤的作用及机制
The role and the mechanism of different concentrations of arsenic trioxide alone or combined with cisplatin on human cervical cancer xenografts
摘要
Abstract
Objective To study the effect and toxicity of different concentrations of arsenic trioxide (As2O3) and cisplatin used alone or in combination on cervical cancer in nude mice. Methods Human cervical cancer cells were inoculated subcutaneously in nude mice, nude mouse xenograft modelas were divided into six observation groups and one control group according to the different treatment ,the control group was given normal saline treatment.The observation group of six groups were treated with arsenic trioxide alone, cisplatin alone and combined use of two. To detect apoptosis by flow cytometry, and the toxic side effect was observed by HE staining. Results Tumor mass and apoptosis rate of cell in observation group were significantly better than the control group, P < 0.05.After the treatment,observation group appeared to blood cell decrease , and cisplatin group appeared bone marrow suppression significantly.Hemoglobin, platelet values significantly lower than control group.After treatment, the nude mice blood urea nitrogen level, alanine aminotransferase values increased.Liver and kidney injury in cisplatin group increased obviously than the control group. Conclusion Arsenic trioxide combined with cisplatin in the treatment of cervical cancer xenograft promote the apoptosis of cancer cells and the clinical therapeutic effect effectively, enhanced the inhibition of cancer cell proliferation, it is worthy of promotion with good clinical effect.关键词
宫颈癌移植瘤/三氧化二砷/顺铂/裸鼠Key words
Cervical cancer xenograft/Arsenic trioxide/Cisplatin/Nude mice分类
医药卫生引用本文复制引用
周曦,陈忠东..不同剂量三氧化二砷单独及联合顺铂对人宫颈癌移植瘤的作用及机制[J].中国医药科学,2015,(1):44-47,4.基金项目
湖南省衡阳市科学技术发展计划（06Kj30）。 （）
