中国医药科学Issue(7)：27-28,42,3.
山莨菪碱联合乌司他丁对重症胰腺炎大鼠模型的应用价值
Application value of high doses of anisodamine combined with ulinastatin in the treatment of rats with severe acute pancreatitis
黎永胜1
作者信息
- 1. 汕头大学医学院第一附属医院急诊科，广东汕头 515041
- 折叠
摘要
Abstract
ObjectiveTo investigate the effects of high doses of anisodamine combined with ulinastatin in the treatment of severe acute pancreatitis (SAP). Methods 90 healthy adult rats were divided into 3 groups according to random number table:the control group 1 (SAP),the control group 2 (SAP rats treated by ulinastatin) and the observation group (SAP rats treated by ulinastatin and high doses of anisodamine),30 rats in each group.Results The level of serum amylase,phospholipase A2 and endotoxin lower in the observation group using high doses of anisodamine combined with ulinastatin than that in the control group,the survival rate on the third day was 73.33%,was significantly higher than that in the control group.The level of serum amylase,phospholipase A2 and endotoxin significantly was lower the control group 2 than that in the control group 1 (P<0.05).Conclusion The high dosage of anisodamine combined with ulinastatin on SAP,can effectively loose sphincter of Oddi,inhibit the protease reaction,inhibit the expression of inflammatory mediators, prolong the survival period of SAP.关键词
重症胰腺炎/山莨菪碱/乌司他丁/存活率Key words
Severe acute pancreatitis/Anisodamine/Ulinastatin/Survival rate分类
医药卫生引用本文复制引用
黎永胜..山莨菪碱联合乌司他丁对重症胰腺炎大鼠模型的应用价值[J].中国医药科学,2015,(7):27-28,42,3.
