中国医药科学Issue(8)：25-28,39,5.
子痫前期的发病机制及临床治疗
The nitric oxide pathway and possible therapeutic options in pre-eclampsia
史翠霞 1曹伟2
作者信息
- 1. 山东省费县人民医院妇产科，山东费县273400
- 2. 山东省费县人民医院骨科，山东费县273400
- 折叠
摘要
Abstract
Pre-eclampsia is a serious multisystem disorder with diverse clinical manifestations. Researches have shown that endothelial dysfunction and reduced nitric oxide bioavailability are likely to play an important role in the maternal and fetal pathophysiology. Lack of treatment modalities that can target the underlying pathophysiological changes and reverse the endothelial dysfunction frequently leads to iatrogenic preterm delivery of the fetus, causing neonatal morbidity and mortality, and maternal morbidity and mortality. Drugs that target various components of the nitric oxide: soluble guanylyl cyclase pathway can help to increase NO bioavailability. The purpose of this review is to outline the current status of clinical research involving these therapeutic modalities in the context of preeclampsia, with the focus being on nitric oxide donors including organic nitrates and S-nitrosothiols; L-arginine, the endogenous precursor of NO;inhibitors of cGMP breakdown including sildenafil, and other novel inhibitors of NO donor metabolism. The advantages and limitations of each modality are outlined and the development into established therapeutic options for preeclampsia is explored.关键词
子痫前期/血管内皮功能障碍/一氧化氮/一氧化氮供体/有机硝酸盐/S-亚硝基谷胱甘肽/L-精氨酸/西地那非Key words
Preeclampsia/Endothelial dysfunction/Nitric oxide/Nitric oxide donors/Organic nitrates/S-nitrosoglutathione/L-arginine/Sildenafil分类
医药卫生引用本文复制引用
史翠霞,曹伟..子痫前期的发病机制及临床治疗[J].中国医药科学,2015,(8):25-28,39,5.
