中国医药科学Issue(8)：37-39,3.
米非司酮联合曲普瑞林治疗子宫肌瘤的临床疗效及安全性研究
The study of the clinical efficacy and safety of mifepristone combined with triptorelin in the treatment of uterine fibroids
摘要
Abstract
Objective To explore the clinical efficacy and safety of mifepristone combined with triptorelin in the treatment of uterine fibroids. Methods 182 cases of patients with uterine fibroids were selected and were randomly divided into the control group (n=91) and observation group (n=91). The patients in the control group were given oral compound mifepristone tablets while patients in the observation group were given muscle triptorelin acetate for injection based on the treatment on group A. The changes of the size of the uterus, the volume of uterine fibroids, Follicle-stimulating hormone, estradiol and the level of hemoglobin in the patients of the two groups were observed and compared before and after the treatment. The total effective rate, incidence of adverse reactions and recurrence rate of patients in two groups were compared. Results Before treatment, the differences of the clinical indexes of patients in two groups were not statistically significant (P>0.05). After treatment, the clinical indexes of the patients in two groups were improved significantly. The level of hemoglobin the observation group was significantly higher than the control group (P<0.05) and the other indexes were significantly lower than those in control group (P <0.05). The effective rate in the observation group was significantly higher than that of the control group (P<0.05) but the recurrence rate was significantly lower than that of the control group (P < 0.05). The incidence of adverse reaction was not statistically significant (P>0.05). Conclusion the treatment of mifepristone combined with triptorelin can effectively improve the clinical indexes of patients with uterine fibroids and efficiency is significantly higher than that of the pure medicine. This method of treatment is much safer and is worth the clinical application.关键词
子宫肌瘤/米非司酮/曲普瑞林/有效性/安全性Key words
Uterine fibroids/Mifepristone/Triptorelin/Efficacy/Safety分类
医药卫生引用本文复制引用
李敬香,蒋素英,陈惠云,吴钦兰,王宏波,燕军..米非司酮联合曲普瑞林治疗子宫肌瘤的临床疗效及安全性研究[J].中国医药科学,2015,(8):37-39,3.基金项目
广东省深圳市宝安区科技局资助项目（20110522）。 （）
