中国医药科学Issue(8)：148-150,3.
VMDT方案和VAD方案治疗多发性骨髓瘤的疗效比较
Comparison of therapeutic effects of VMDT scheme and VAD scheme treatment of multiple myeloma
黄文添 1陆森 1陆粤就 1龙燕 1李业锦 1梁有为1
作者信息
- 1. 广东省信宜市人民医院肿瘤血液科，广东信宜525300
- 折叠
摘要
Abstract
Objective To observe and to compare the clinical effect and adverse reaction of VMDT scheme and VAD scheme in the treatment of multiple myeloma. Methods 64 patients with multiple myeloma, who were received and cured in our hospital from August 2007 to August 2014, were selected and randomly divided into VMDT group and VAD group, with 32 cases in each group. To respectively adopt VMDT scheme and VAD scheme with 4 courses of chemotherapy, to compare the clinical effect and adverse reaction between the two groups. Results The clinical effective rate in VMDT group(81.25 % ) was obviously better than which in VAD group(56.25 % ), the differences was statically significant(P < 0.05). Of the primary clinical index aspect, M protein in VMDT group(62.50%) and in VAD group(50.00%) had declined more than 50%, myeloma cells in VMDT group(62.50%) and in VAD group(53.13%) had declined more than 80%, hemoglobin in VMDT group(56.25%) and in VAD group(50.00%) had risen 20g/L, which in VMDT group was significantly better than which in VAD group, the differences was statically significant (P<0.05). The adverse reaction of constipation, fatigue, hypodynamia, function lesion of liver and kidney in VMDT group was siginificantly better than which in VAD group(P<0.05), the adverse reaction of dry mouth, limb numbness, digestive tract symptom in VMDT group was no statistical significance (P > 0.05). Conclusion VMDT scheme is much better than conventional VAD scheme with lesser glucocorticoid, has higher clinical effective rate and lower side effect, is applied compatibly in primary hospital, and is worthy of clinical popularization and application.关键词
多发性骨髓瘤/VMDT 方案/VAD 方案/临床疗效Key words
Multiple myeloma/VMDT scheme/VAD scheme/Clinical effect分类
医药卫生引用本文复制引用
黄文添,陆森,陆粤就,龙燕,李业锦,梁有为..VMDT方案和VAD方案治疗多发性骨髓瘤的疗效比较[J].中国医药科学,2015,(8):148-150,3.
